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Although biotin deficiency in humans is rare, it does occur.
SymptomsThe symptoms of biotin deficiency include:
- generalized skin rash around eyes, nose,mouth, ears and genital areas
- hair loss
- conjunctivitisÂ
- neurological abnormalities
The facial appearance associated with the deficiency, with the rash around the eyes, nose and mouth along with an unusual distribution of facial fat, is called biotin deficiency facies.
In biotin deficient babies, the neurological findings are hypotonia, lethargy and developmental delay. In adults, the neurological findings are lethargy, depression, hallucinations and paresthesias of the extremities.
Biotin deficiencies may occur under certain conditions, e.g., during the first trimester of pregnancy, and can result in birth defects.
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